August 11, 2022

What Anti-Aging Longevity Supplements Does Dr David Sinclair Take? NMN Resveratrol

In this article I detail the longevity supplements that Dr David Sinclair takes including dosage. Also look into other aspects of his research and book, Lifespan: Why We Age―and Why We Don’t Have To

David Sinclair Geneticist Longevity and Healthspan Researcher

In his book mentioned below and in several podcasts including Joe Rogan Experience, Lewis Howes the school of Greatness, David has detailed the supplements and the dosage that he takes, which is summarised below:

  • Nicotinamide Mononucleotide (NMN) 1g/1000mg daily in the morning
  • Trans Resveratrol 1g / 1000 mg in the morning daily, the effectiveness of resveratrol is increased when dissolved in or taken with high fat so Dave takes it with a yoghurt he makes at home as below
    • Yoghurt Bravo Pro Biotic
  • Metformin 1 g in the evening (Does not take on days he goes to the Gym), note most countires Metformin is a prescription medication for Type 2 diabetes, which has been shown to decrease the risk of cancer and
  • Vitamin D3 with K2 for its immune boosting benefits dose unknown

David also takes statin this is not for any longevity benefits but because he has high cholesterol in his family.

If you have any questions or additional insights to provide or other opinions please drop a comment below or via the Green comment bubble on the left.

Other than Supplements what does Dr Sinclair do to improve his lifespan?

Other than supplements David Sinclair does the following to further cement his longevity regime:

  • Reducing or Avoiding sugars and refined carbohydrates which also includes orange juice.
  • Intermittent fasting, on most days he follows a 20/4 fasting plan by skipping both breakfast and lunch. Periods of huger including some calorie restriction increases sirtuin activation
  • Eating a large amount of green vegetables
  • Limiting protein, eliminating where possible red meats with a preference for White meats including chicken and fish.
  • Get plenty of sleep
  • Exercise Frequently

Who is Dr David Sinclair?

David Sinclair Geneticist Longevity and Healthspan Researcher

Dr Sinclair is a Professor of genetics and co-Director of the Paul F. Glenn Center at Harvard Medical School and also Professor at the University of New South Wales UNSW is well known for his research into aging and is the author of the New York Times best seller Lifespan: Why We Age – and Why We Don’t Have To (Amazon link)

Born in Sydney, Australia in 1969 Dr Sinclair looks years younger than his current age of 50, its hard not to think that his youthfulness is at least in part due to the anti-aging supplements he takes on a daily basis.

Being a researcher and with strict ethics Dr Sinclair doesn’t promote any products however in his book and on several of the podcasts he has been interviewed on including Joe Rogan Experience he has detailed the types of supplements he takes and what else he does to extend his lifespan.

Companies David Sinclair has been founded co-founded or been involved with

Sirtris Pharmaceuticals was purchased by and made a subsidiary of GlaxoSmithKline in 2008

Genocea Biosciences co-founder 2006, a company developing vaccines using Antigens which stimulate T Cells

OvaScience publicly traded bio tech co-founded by David, has developed two female infertility products based on the work by David’s research on mitochondria and Jonathan Tilly’s research on mammalian oogonial stem cells

CohBar co-founder looking at the use of mitochondria to develop novel peptides.

Life Biosciences Co-Founder and Chairman of the board, this company is involved investigating the molecular pathways behind aging and age-related diseases through and has several subsidiary companies including Jumpstart Fertility, Senolytx & Continuum Biosciences

Highlights and awards from David Sinclair’s career

Working at Massachusetts Institute of Technology (MIT) under Leonard P. Guarente he discovered that Sirtuin 1 sir 2slows aging in yeast by reducing the accumulation of extrachromosomal rDNA circles.

Then later after his move to Harvard medical school he collaborated with a team from Biomol to verify that polyphenols including resveratrol and quercetin could activate sir2Frontiers in Aging and Regeneration Award
Featured in five books & two documentary movies
Featured on CBS 60 Minutes
Featured in Morgan Freeman’s “Through the Wormhole.”Serves on the board of American Federation for Aging Research and the Sanford Lorraine Cross Award both no-profitReceived more than 35 awards including:

  • Time 100 most influential people awarded in 2014
  • Time Magazine’s 50 Most Influential People in Health Care in 2018
  • Awarded Officer of the Order of Australia (AO) in 2018 for “distinguished service to medical research into the biology of ageing and lifespan extension, as a geneticist and academic, to biosecurity initiatives, and as an advocate for the study of science”.
  • Australian Medical Research Medal

Dave Sinclair’s NY Times Best Selling Book: Lifespan: Why We Age―and Why We Don’t Have To

In his book cowritten by author Matthew D. LaPlante starts by looking at family his up brining in the Northern Beaches of Sydney Australia then takes a look at the breakthroughs both he and colleagues in the field of genetics, aging, lifespan, what is currently being researched/developed and what he sees coming over the horizon. If you would like to pickup this book please help support this site by purchasing this link: Lifespan Book

Topics he covers in the book include:

  • Research that has been done into Optic nerve regeneration in mice
  • DNA and the role of the epigenome (epigenetics)
  • DNA Methylation Clock i.e. Horvath clock and how he tracks his biomarkers
  • Telomeres/Telomere Length
  • Survival Circuit
  • NAD+ levels can be boosted with NMN and NR
  • Tracking biomarkers
  • Blue zones around the world and what we can learn from them
  • Hallmarks of aging
    • Past theories of aging
      • DNA Mutations
      • Free radicals
  • Information theory of aging
    • Sirtuins
    • Epigenetic changes cause aging
  • AMPK and mTOR
  • Strategies for living longer
    • Hormesis
    • Promising compounds
      • Resveratrol and Coenzyme Q10 CoQ10
      • NAD+ boosting and precursors like NR nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)
      • Metformin
      • Rapamycin
  • Use of gene editing/therapy tools like CRISPR for the future of longevity
  • Extrachromosomal Ribosomal DNA Circle (ERC)
  • Epigenetic Drift and Epigenetic Noise
  • Cellular Senescence

Personally, I own both the Audible and printed copy of this book and it was a great read which at times I go pickup again to re-read, as its very technical book I find myself with a greater understanding each time I read.

Podcasts Videos and Events he has appeared on and featured in

IF YOU Want To Live Longer WATCH THIS (How To Age In Reverse)| David Sinclair & Lewis Howes

A Harvard Geneticist Is Extending Human Lifespan: David Sinclair, PhD | Rich Roll Podcast

David Sinclair Is Extending Human Lifespan | Rich Roll Podcast

A Cure for Ageing?: David Sinclair at TEDxSydney

David Sinclair – Cracking & reversing the aging clock – Science Unlimited 2019

Why We Age and Why We Don’t Have To | David Sinclair | Talks at Google

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